The linear excisional wound: an improved model for human ex vivo wound epithelialization studies
نویسندگان
چکیده
منابع مشابه
Silicone ring implantation in an excisional murine wound model.
UNLABELLED A good animal model for wound healing is indispensable for researchers to study the basic mechanism of tissue repair, and to develop strategies for clinical treatment. Small mammalian wound healing models are the most popular animal models for wound healing research because they are inexpensive, readily obtainable, and easy to handle. One significant challenge of using mice to evalua...
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Corneal disease is a significant cause of decreased vision or blindness in the horse worldwide. Numerous topical and systemic drugs over a prolonged period of time may be used to treat an equine corneal ulcer. Despite the high prevalence of corneal disease and ulceration in the horse, and the complexity of corneal wound healing, research is limited and more heavily devoted to in vivo studies wh...
متن کاملWound re-epithelialization: modulating keratinocyte migration in wound healing.
An essential feature of a healed wound is the restoration of an intact epidermal barrier through wound epithelialization, also known as re-epithelialization. The directed migration of keratinocytes is critical to wound epithelialization and defects in this function are associated with the clinical phenotype of chronic non-healing wounds. A complex balance of signaling factors and surface protei...
متن کاملHuman lactoferrin stimulates skin keratinocyte function and wound re-epithelialization.
BACKGROUND Human lactoferrin (hLF), a member of the transferrin family, is known for its antimicrobial and anti-inflammatory effects. Recent studies on various nonskin cell lines indicate that hLF may have a stimulatory effect on cell proliferation. OBJECTIVES To study the potential role of hLF in wound re-epithelialization. MATERIALS AND METHODS The effects of hLF on cell growth, migration...
متن کاملA primary burn wound does not slow the contraction rate of an adjacent excisional wound.
The response to major burn injury includes systemic release of mediators that may have an effect on wound healing. The authors evaluated the effect of a burn injury on the contraction of an excisional wound adjacent to the burn, and the effect of plasma derived from burn-injured animals on the contraction of the fibroblast-populated collagen matrix (FPCM). Nine rats (90-100 days old) under anes...
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ژورنال
عنوان ژورنال: Skin Research and Technology
سال: 2011
ISSN: 0909-752X
DOI: 10.1111/j.1600-0846.2011.00528.x